{"id":16296,"date":"2026-08-15T10:56:23","date_gmt":"2026-08-15T10:56:23","guid":{"rendered":"https:\/\/gs25deocksu.com\/?p=16296"},"modified":"2026-08-15T10:56:42","modified_gmt":"2026-08-15T10:56:42","slug":"opa1-fat-intake-brain-neurons","status":"publish","type":"post","link":"https:\/\/gs25deocksu.com\/ja\/2026\/08\/opa1-fat-intake-brain-neurons.html","title":{"rendered":"\uae30\ub984\uc9c4 \uc74c\uc2dd \ub2f9\uae30\ub294 \uc774\uc720, \ub1cc \ub2e8\ubc31\uc9c8 OPA1\uc774 \uc9c0\ubc29 \uc12d\ucde8\u00b7\uccb4\uc911 \uc870\uc808\ud55c\ub2e4\ub294 \uc0dd\uc950 \uc5f0\uad6c"},"content":{"rendered":"<p><!-- STEP 1 START --><\/p>\n<div style=\"background:linear-gradient(90deg,#E8F8FC 0%,#FFFFFF 100%);border-left:5px solid #0072CE;border-radius:12px;box-sizing:border-box;color:#004B87;font-size:1.08rem;font-weight:800;line-height:1.7;margin:16px 0;padding:18px 20px;width:100%;max-width:100%;\">\ubc30\uac00 \uc544\uc8fc \uace0\ud508 \uac83\ub3c4 \uc544\ub2cc\ub370 \uae30\ub984\uc9c4 \uc74c\uc2dd\uc774 \uc720\ub3c5 \ub2f9\uae38 \ub54c\uac00 \uc788\uc8e0. \ucd5c\uadfc \uc0dd\uc950 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc774\ub7f0 \uc9c0\ubc29 \uc12d\ucde8 \ud589\ub3d9\uc5d0 \ub1cc \uc2e0\uacbd\uc138\ud3ec \uc18d OPA1\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uad00\uc5ec\ud560 \uac00\ub2a5\uc131\uc774 \uc81c\uc2dc\ub410\uc2b5\ub2c8\ub2e4.<\/div>\n<p><!-- FEATURED IMAGE SLOT\n\uc6cc\ub4dc\ud504\ub808\uc2a4\uc5d0\uc11c \ub300\ud45c \uc774\ubbf8\uc9c0\ub97c \uc124\uc815\ud558\uace0 \uc774 \uc704\uce58\uc5d0\ub3c4 \uc774\ubbf8\uc9c0 \ube14\ub85d\uc744 \uc0bd\uc785\ud558\uc138\uc694.\n\uad8c\uc7a5 ALT: \ub1cc \uc2e0\uacbd\uc138\ud3ec\uc640 \uc9c0\ubc29 \uc12d\ucde8 \uc870\uc808 \uc5f0\uad6c\ub97c \ud45c\ud604\ud55c \uac1c\ub150 \uc774\ubbf8\uc9c0\n--><\/p>\n<p style=\"color:#243447;line-height:1.9;margin:18px 0;\">\uae30\ub984\uc9c4 \uc74c\uc2dd\uc744 \uc88b\uc544\ud558\ub294 \uc774\uc720\ub97c \ub2e8\uc21c\ud788 \u2018\uc758\uc9c0 \ubd80\uc871\u2019\uc774\ub77c\uace0 \uc0dd\uac01\ud558\uae30 \uc27d\uc9c0\ub9cc, \uc2dd\uc695\uacfc \uc74c\uc2dd \uc120\ud0dd\uc5d0\ub294 \ub1cc\uc758 \uc5ec\ub7ec \uc2e0\ud638\uac00 \ubcf5\uc7a1\ud558\uac8c \uad00\uc5ec\ud569\ub2c8\ub2e4. \uc77c\ubcf8 \uc624\uc0ac\uce74\uacf5\ub9bd\ub300 \uc5f0\uad6c\uc9c4\uc740 \uadf8\uc911\uc5d0\uc11c\ub3c4 \uc2dc\uc0c1\ud558\ubd80\uc758 \uba5c\ub77c\ub178\ucf54\ub974\ud2f4-4 \uc218\uc6a9\uccb4(MC4R) \uc2e0\uacbd\uc138\ud3ec\uc5d0 \uc788\ub294 <strong style=\"color:#004B87;\">OPA1(optic atrophy 1)<\/strong>\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc5d0 \uc8fc\ubaa9\ud588\uc5b4\uc694.<\/p>\n<p style=\"color:#243447;line-height:1.9;margin:18px 0;\">\uc5f0\uad6c\uc9c4\uc740 \uc815\uc0c1 \uc0dd\uc950\uc640 MC4R \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c OPA1\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uc81c\uac70\ud55c \uc0dd\uc950\ub97c \ube44\uad50\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc OPA1 \uacb0\ud54d \uc0dd\uc950\uc5d0\uc11c \uba39\uc774 \uc12d\ucde8\uc640 \uc9c0\ubc29 \uc12d\ucde8, \uccb4\uc911 \uc99d\uac00 \uc591\uc0c1\uc774 \ub2ec\ub77c\uc84c\uace0 \uc131\ubcc4\uc5d0 \ub530\ub77c\uc11c\ub3c4 \ucc28\uc774\uac00 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ud765\ubbf8\ub85c\uc6b4 \uacb0\uacfc\uc9c0\ub9cc, \uc5b4\ub514\uae4c\uc9c0\ub098 <strong style=\"color:#004B87;\">\uc0dd\uc950 \uc2e4\ud5d8\uc5d0\uc11c \ud655\uc778\ub41c \uc5f0\uad6c<\/strong>\ub77c\ub294 \uc810\uc740 \uaf2d \uac19\uc774 \ubd10\uc57c \ud569\ub2c8\ub2e4.<\/p>\n<nav aria-label=\"\ubaa9\ucc28\" style=\"background:#F3FBFD;border:1px solid #B8E9F2;border-top:4px solid #0072CE;border-radius:12px;box-sizing:border-box;margin:24px 0;padding:20px;width:100%;max-width:100%;\">\n<p style=\"color:#004B87;font-size:1.15rem;font-weight:800;margin:0 0 12px;\">\ubaa9\ucc28<\/p>\n<ol style=\"color:#243447;line-height:1.9;margin:0;padding-left:22px;\">\n<li><a href=\"#opa1-role\" style=\"color:#00539F;font-weight:700;\">OPA1\uc740 \uc5b4\ub5a4 \ub2e8\ubc31\uc9c8\uc77c\uae4c<\/a><\/li>\n<li><a href=\"#mouse-experiment\" style=\"color:#00539F;font-weight:700;\">\uc5f0\uad6c\uc9c4\uc740 \uc0dd\uc950 \uc2e4\ud5d8\uc744 \uc5b4\ub5bb\uac8c \uc9c4\ud589\ud588\ub098<\/a><\/li>\n<li><a href=\"#fat-intake-weight\" style=\"color:#00539F;font-weight:700;\">OPA1\uc744 \uc5c6\uc560\uc790 \uc9c0\ubc29 \uc12d\ucde8\uc640 \uccb4\uc911\uc740 \uc5b4\ub5bb\uac8c \ub2ec\ub77c\uc84c\ub098<\/a><\/li>\n<li><a href=\"#sex-differences\" style=\"color:#00539F;font-weight:700;\">\uc218\ucef7\uacfc \uc554\ucef7\uc5d0\uc11c \uc65c \ub2e4\ub978 \ubcc0\ud654\uac00 \ub098\ud0c0\ub0ac\ub098<\/a><\/li>\n<li><a href=\"#setmelanotide-response\" style=\"color:#00539F;font-weight:700;\">MC4R \uce58\ub8cc\uc81c \ubc18\uc751\uc5d0\uc11c\ub3c4 \ub098\ud0c0\ub09c \ucc28\uc774<\/a><\/li>\n<li><a href=\"#human-interpretation\" style=\"color:#00539F;font-weight:700;\">\uc0ac\ub78c\uc758 \uc2dd\uc695\uacfc \ube44\ub9cc\uc5d0 \ubc14\ub85c \uc801\uc6a9\ud574\ub3c4 \ub420\uae4c<\/a><\/li>\n<\/ol>\n<\/nav>\n<p><!-- STEP 1 END --><!-- STEP 2 START --><\/p>\n<h2 id=\"opa1-role\" style=\"border-left:5px solid #0072CE;box-sizing:border-box;color:#00539F;font-size:1.55rem;line-height:1.45;margin:30px 0 16px;padding-left:12px;width:100%;max-width:100%;\">OPA1\uc740 \uc5b4\ub5a4 \ub2e8\ubc31\uc9c8\uc77c\uae4c<\/h2>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">OPA1\uc740 \uc138\ud3ec \uc548\uc5d0\uc11c \uc5d0\ub108\uc9c0\ub97c \ub9cc\ub4dc\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uad6c\uc870\uc640 \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \uad00\uc5ec\ud558\ub294 \uc735\ud569 \ub2e8\ubc31\uc9c8\uc785\ub2c8\ub2e4. \uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c\ub294 OPA1 \uc790\uccb4\ub97c \ubab8 \uc804\uccb4\uc5d0\uc11c \uc0b4\ud3b4\ubcf8 \uac83\uc774 \uc544\ub2c8\ub77c, \uc2dd\uc695\uacfc \uccb4\uc911 \uc870\uc808\uc5d0 \uad00\uc5ec\ud558\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc9c4 <strong style=\"color:#004B87;\">MC4R \uc2e0\uacbd\uc138\ud3ec \uc548\uc758 OPA1<\/strong>\uc5d0 \ucd08\uc810\uc744 \ub9de\ucdc4\uc2b5\ub2c8\ub2e4.<\/p>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc5f0\uad6c\uc9c4\uc774 \uad81\uae08\ud588\ub358 \uac74 \ube44\uad50\uc801 \uba85\ud655\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c OPA1\uc774 \uc81c\ub300\ub85c \uc791\ub3d9\ud558\uc9c0 \uc54a\uc73c\uba74 \uc74c\uc2dd \uc12d\ucde8\ub7c9\uc774\ub098 \uc9c0\ubc29\uc744 \uc120\ud0dd\ud558\ub294 \ud589\ub3d9, \uccb4\uc911 \uc870\uc808\uc774 \ub2ec\ub77c\uc9c8 \uc218 \uc788\ub290\ub0d0\ub294 \uac83\uc774\uc5c8\uc8e0. \uc989 \ub2e8\uc21c\ud788 \u2018\uc9c0\ubc29\uc744 \uc88b\uc544\ud55c\ub2e4\u2019\ub294 \ud589\ub3d9\ubcf4\ub2e4 \uadf8 \ub4a4\uc5d0 \uc788\ub294 \uc2e0\uacbd\uc138\ud3ec\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc640 \uc2dd\uc695 \uc870\uc808 \uc2e0\ud638\ub97c \ub4e4\uc5ec\ub2e4\ubcf8 \uc5f0\uad6c\ub77c\uace0 \ubcfc \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p style=\"background:#F3FBFD;border-left:4px solid #05C3DE;border-radius:8px;box-sizing:border-box;color:#243447;line-height:1.85;margin:18px 0;padding:14px 16px;width:100%;max-width:100%;\"><strong>\uc774\ubc88 \uc5f0\uad6c\uc758 \ud575\uc2ec\uc740 OPA1\uc774 \uc9c0\ubc29 \uc12d\ucde8\ub97c \uc9c1\uc811 \u2018\ucf1c\uace0 \ub044\ub294 \uc2a4\uc704\uce58\u2019\ub77c\uace0 \ud655\uc815\ud55c \uac83\uc774 \uc544\ub2c8\ub77c, MC4R \uc2e0\uacbd\uc138\ud3ec\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc640 \uc74c\uc2dd \uc12d\ucde8 \uc870\uc808\uc5d0 \uad00\uc5ec\ud560 \uac00\ub2a5\uc131\uc744 \uc0dd\uc950\uc5d0\uc11c \ud655\uc778\ud588\ub2e4\ub294 \uc810\uc785\ub2c8\ub2e4.<\/strong><\/p>\n<h2 id=\"mouse-experiment\" style=\"border-left:5px solid #0072CE;box-sizing:border-box;color:#00539F;font-size:1.55rem;line-height:1.45;margin:30px 0 16px;padding-left:12px;width:100%;max-width:100%;\">\uc5f0\uad6c\uc9c4\uc740 \uc0dd\uc950 \uc2e4\ud5d8\uc744 \uc5b4\ub5bb\uac8c \uc9c4\ud589\ud588\ub098<\/h2>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc5f0\uad6c\uc9c4\uc740 \uc815\uc0c1 \uc0dd\uc950\uc640 MC4R \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c OPA1\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uc81c\uac70\ud55c \uc0dd\uc950\ub97c \ube44\uad50\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub9ac\uace0 \uc0dd\uc950\uc5d0\uac8c \uc77c\ubc18 \uba39\uc774\ubfd0 \uc544\ub2c8\ub77c \uc2dd\uc774 \uc9c0\ubc29 \uacf5\uae09\uc6d0\uc73c\ub85c \ucf69\uae30\ub984\uc744 \uc790\uc720\ub86d\uac8c \uc12d\ucde8\ud560 \uc218 \uc788\ub3c4\ub85d \ud574 \uc9c0\ubc29\uc5d0 \ub300\ud55c \uc12d\ucde8 \ud589\ub3d9\uc774 \uc5b4\ub5bb\uac8c \ub2ec\ub77c\uc9c0\ub294\uc9c0 \uc0b4\ud3b4\ubd24\uc2b5\ub2c8\ub2e4.<\/p>\n<div style=\"box-sizing:border-box;margin:18px 0;max-width:100%;overflow-x:auto;width:100%;\">\n<table style=\"border-collapse:collapse;min-width:620px;width:100%;\">\n<thead>\n<tr>\n<th style=\"background:#0072CE;border:1px solid #0072CE;color:#FFFFFF;padding:12px;text-align:left;\">\ube44\uad50 \ud56d\ubaa9<\/th>\n<th style=\"background:#0072CE;border:1px solid #0072CE;color:#FFFFFF;padding:12px;text-align:left;\">\uc815\uc0c1 \uc0dd\uc950<\/th>\n<th style=\"background:#0072CE;border:1px solid #0072CE;color:#FFFFFF;padding:12px;text-align:left;\">OPA1 \uacb0\ud54d \uc0dd\uc950<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#F3FBFD;\">\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">MC4R \uc2e0\uacbd\uc138\ud3ec OPA1<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc815\uc0c1\uc801\uc73c\ub85c \uc874\uc7ac<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc120\ud0dd\uc801\uc73c\ub85c \uc81c\uac70<\/td>\n<\/tr>\n<tr>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc8fc\uc694 \uad00\ucc30<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uba39\uc774\u00b7\uc9c0\ubc29 \uc12d\ucde8\uc640 OPA1 \ubc18\uc751 \ud655\uc778<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uba39\uc774\u00b7\uc9c0\ubc29 \uc12d\ucde8\uc640 \uccb4\uc911 \ubcc0\ud654 \ube44\uad50<\/td>\n<\/tr>\n<tr style=\"background:#F3FBFD;\">\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc131\ubcc4 \ubd84\uc11d<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc218\ucef7\uacfc \uc554\ucef7 \uac01\uac01 \uad00\ucc30<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc218\ucef7\uacfc \uc554\ucef7\uc758 \ubcc0\ud654 \ucc28\uc774 \ud655\uc778<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc815\uc0c1 \uc218\ucef7 \uc0dd\uc950\uc5d0\uc11c\ub294 \ucf69\uae30\ub984\uc744 \uc12d\ucde8\ud55c \ub4a4 OPA1 \ubc1c\ud604\uc774 \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4. \ubc18\uba74 \uc815\uc0c1 \uc554\ucef7\uc5d0\uc11c\ub294 \uac19\uc740 \ubcc0\ud654\uac00 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \ucc28\uc774\ub97c \ubc14\ud0d5\uc73c\ub85c OPA1\uc774 \uc9c0\ubc29 \uc12d\ucde8\uc5d0 \ubc18\uc751\ud558\ub294 \ubc29\uc2dd \uc790\uccb4\uac00 \uc131\ubcc4\uc5d0 \ub530\ub77c \ub2e4\ub97c \uac00\ub2a5\uc131\ub3c4 \uc0b4\ud3b4\ubd24\uc2b5\ub2c8\ub2e4.<\/p>\n<h2 id=\"fat-intake-weight\" style=\"border-left:5px solid #0072CE;box-sizing:border-box;color:#00539F;font-size:1.55rem;line-height:1.45;margin:30px 0 16px;padding-left:12px;width:100%;max-width:100%;\">OPA1\uc744 \uc5c6\uc560\uc790 \uc9c0\ubc29 \uc12d\ucde8\uc640 \uccb4\uc911\uc740 \uc5b4\ub5bb\uac8c \ub2ec\ub77c\uc84c\ub098<\/h2>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">MC4R \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c OPA1\uc744 \uc81c\uac70\ud55c \uc0dd\uc950\ub294 \uc815\uc0c1 \uc0dd\uc950\ubcf4\ub2e4 \uba39\uc774\ub97c \ub354 \ub9ce\uc774 \uc12d\ucde8\ud588\uc2b5\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uc218\ub85d \uccb4\uc911 \uc99d\uac00 \ud3ed\ub3c4 \ucee4\uc838 \uacb0\uad6d \ube44\ub9cc\ud55c \uc0c1\ud0dc\uac00 \uad00\ucc30\ub410\uace0, \uc77c\ubc18 \uc0ac\ub8cc\uc640 \ucf69\uae30\ub984\uc744 \ud568\uaed8 \uc81c\uacf5\ud588\uc744 \ub54c\ub294 \uc9c0\ubc29 \uc12d\ucde8\uac00 \ub354 \ub298\uba74\uc11c \uccb4\uc911\ub3c4 \ucd94\uac00\ub85c \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<ul style=\"background:#F3FBFD;border-left:4px solid #05C3DE;border-radius:8px;box-sizing:border-box;color:#243447;line-height:1.85;margin:18px 0;padding:16px 18px 16px 38px;width:100%;max-width:100%;\">\n<li style=\"margin:7px 0;\">OPA1 \uacb0\ud54d \uc0dd\uc950\ub294 \uc815\uc0c1 \uc0dd\uc950\ubcf4\ub2e4 \uc804\uccb4 \uba39\uc774 \uc12d\ucde8\ub7c9\uc774 \ub9ce\uc558\uc2b5\ub2c8\ub2e4.<\/li>\n<li style=\"margin:7px 0;\">\ub098\uc774\uac00 \ub4e4\uba74\uc11c \uccb4\uc911\uc774 \ub354 \ub9ce\uc774 \uc99d\uac00\ud558\ub294 \ubcc0\ud654\uac00 \uad00\ucc30\ub410\uc2b5\ub2c8\ub2e4.<\/li>\n<li style=\"margin:7px 0;\">\uc77c\ubc18 \uc0ac\ub8cc\uc640 \ucf69\uae30\ub984\uc744 \ud568\uaed8 \uc8fc\uc5c8\uc744 \ub54c \uc9c0\ubc29 \uc12d\ucde8\uac00 \ub354 \ub298\uc5c8\uc2b5\ub2c8\ub2e4.<\/li>\n<li style=\"margin:7px 0;\">\uc9c0\ubc29 \uc12d\ucde8\uc640 \uccb4\uc911 \uc99d\uac00 \uc591\uc0c1\uc740 \uc554\ucef7\uc5d0\uc11c \ub354 \ud06c\uac8c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/li>\n<\/ul>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc774 \uacb0\uacfc\ub294 MC4R \uc2e0\uacbd\uc138\ud3ec\uc758 OPA1\uc774 \uc74c\uc2dd \uc12d\ucde8\ub7c9\uacfc \uc9c0\ubc29 \uc120\ud0dd, \uccb4\uc911 \uc870\uc808 \uacfc\uc815\uc5d0 \uad00\uc5ec\ud55c\ub2e4\ub294 \uc5f0\uad6c\uc9c4\uc758 \ud574\uc11d\uc744 \ub4b7\ubc1b\uce68\ud569\ub2c8\ub2e4. \ub2e4\ub9cc \ud2b9\uc815 \uc74c\uc2dd\uc744 \uc88b\uc544\ud558\ub294 \uc0ac\ub78c\uc5d0\uac8c OPA1 \uc774\uc0c1\uc774 \uc788\ub2e4\ub294 \uc758\ubbf8\ub294 \uc544\ub2d9\ub2c8\ub2e4. \uc0ac\ub78c\uc758 \uc2dd\uc695\uacfc \uccb4\uc911\uc740 \uc720\uc804, \uc0dd\ud65c\ud658\uacbd, \uc218\uba74, \uc2a4\ud2b8\ub808\uc2a4, \uc74c\uc2dd \uc811\uadfc\uc131 \ub4f1 \ub2e4\uc591\ud55c \uc694\uc778\uc758 \uc601\ud5a5\uc744 \ubc1b\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><!-- STEP 2 END --><!-- STEP 3 START --><\/p>\n<h2 id=\"sex-differences\" style=\"border-left:5px solid #0072CE;box-sizing:border-box;color:#00539F;font-size:1.55rem;line-height:1.45;margin:30px 0 16px;padding-left:12px;width:100%;max-width:100%;\">\uc218\ucef7\uacfc \uc554\ucef7\uc5d0\uc11c \uc65c \ub2e4\ub978 \ubcc0\ud654\uac00 \ub098\ud0c0\ub0ac\ub098<\/h2>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \ud2b9\ud788 \ub208\uc5d0 \ub748 \ubd80\ubd84\uc740 \uc131\ubcc4 \ucc28\uc774\uc785\ub2c8\ub2e4. \uc815\uc0c1 \uc218\ucef7 \uc0dd\uc950\ub294 \ucf69\uae30\ub984 \uc12d\ucde8 \ud6c4 MC4R \uc2e0\uacbd\uc138\ud3ec\uc758 OPA1 \ubc1c\ud604\uc774 \uc99d\uac00\ud588\uc9c0\ub9cc \uc554\ucef7\uc5d0\uc11c\ub294 \uac19\uc740 \ubc18\uc751\uc774 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub610 OPA1\uc744 \uc81c\uac70\ud588\uc744 \ub54c \ub098\ud0c0\ub09c \uc9c0\ubc29 \uc12d\ucde8\uc640 \uccb4\uc911 \uc99d\uac00 \ubcc0\ud654\ub294 \uc554\ucef7\uc5d0\uc11c \ub354 \ud06c\uac8c \uad00\ucc30\ub410\uc2b5\ub2c8\ub2e4.<\/p>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc5f0\uad6c\uc9c4\uc740 \uc774\ub7f0 \uacb0\uacfc\uac00 \ube44\ub9cc\uc5d0 \ucde8\uc57d\ud55c \uc815\ub3c4\ub098 \uc2dd\uc695 \uc870\uc808 \ubc18\uc751\uc774 \uc131\ubcc4\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c8 \uc218 \uc788\ub294 \uc774\uc720\ub97c \uc774\ud574\ud558\ub294 \ub2e8\uc11c\uac00 \ub420 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\uc2b5\ub2c8\ub2e4. \ub2e4\ub9cc \uc774 \uacb0\uacfc\ub9cc\uc73c\ub85c \uc0ac\ub78c\uc758 \ub0a8\ub140 \ucc28\uc774\ub97c \uc124\uba85\ud558\uac70\ub098 \ud2b9\uc815 \uc131\ubcc4\uc774 \uae30\ub984\uc9c4 \uc74c\uc2dd\uc5d0 \ub354 \ucde8\uc57d\ud558\ub2e4\uace0 \ub2e8\uc815\ud560 \uc218\ub294 \uc5c6\uc2b5\ub2c8\ub2e4.<\/p>\n<p style=\"background:#F3FBFD;border-left:4px solid #0072CE;border-radius:8px;box-sizing:border-box;color:#243447;line-height:1.85;margin:18px 0;padding:14px 16px;width:100%;max-width:100%;\"><strong>\uc131\ubcc4 \ucc28\uc774\uac00 \uad00\ucc30\ub410\ub2e4\ub294 \uc810\uc740 \ud765\ubbf8\ub86d\uc9c0\ub9cc, \uc0ac\ub78c\uc5d0\uac8c \uac19\uc740 \uc0dd\ubb3c\ud559\uc801 \ucc28\uc774\uac00 \ub098\ud0c0\ub098\ub294\uc9c0\ub294 \ubcc4\ub3c4\uc758 \uc784\uc0c1 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/strong><\/p>\n<h2 id=\"setmelanotide-response\" style=\"border-left:5px solid #0072CE;box-sizing:border-box;color:#00539F;font-size:1.55rem;line-height:1.45;margin:30px 0 16px;padding-left:12px;width:100%;max-width:100%;\">MC4R \uce58\ub8cc\uc81c \ubc18\uc751\uc5d0\uc11c\ub3c4 \ub098\ud0c0\ub09c \ucc28\uc774<\/h2>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc5f0\uad6c\uc9c4\uc740 MC4R\uc744 \ud65c\uc131\ud654\ud558\ub294 \uc57d\ubb3c\uc778 \uc138\ud2b8\uba5c\ub77c\ub178\ud0c0\uc774\ub4dc(setmelanotide)\uc5d0 \ub300\ud55c \ubc18\uc751\ub3c4 \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4. \uc2e4\ud5d8\uc5d0\uc11c \uc774 \uc57d\ubb3c\uc740 \uc815\uc0c1 \uc218\ucef7\uacfc OPA1\uc774 \uacb0\ud54d\ub41c \uc218\ucef7 \ubaa8\ub450\uc758 \uc2dd\uc695\uc744 \uc5b5\uc81c\ud588\uc9c0\ub9cc, OPA1\uc774 \uacb0\ud54d\ub41c \uc554\ucef7\uc5d0\uc11c\ub294 \uc2dd\uc695 \uc5b5\uc81c \ud6a8\uacfc\uac00 \ud06c\uac8c \ub5a8\uc5b4\uc84c\uc2b5\ub2c8\ub2e4.<\/p>\n<div style=\"box-sizing:border-box;margin:18px 0;max-width:100%;overflow-x:auto;width:100%;\">\n<table style=\"border-collapse:collapse;min-width:620px;width:100%;\">\n<thead>\n<tr>\n<th style=\"background:#0072CE;border:1px solid #0072CE;color:#FFFFFF;padding:12px;text-align:left;\">\uc2e4\ud5d8\uad70<\/th>\n<th style=\"background:#0072CE;border:1px solid #0072CE;color:#FFFFFF;padding:12px;text-align:left;\">\uc138\ud2b8\uba5c\ub77c\ub178\ud0c0\uc774\ub4dc \ubc18\uc751<\/th>\n<th style=\"background:#0072CE;border:1px solid #0072CE;color:#FFFFFF;padding:12px;text-align:left;\">\uc5f0\uad6c\uc5d0\uc11c\uc758 \uc758\ubbf8<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#F3FBFD;\">\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc815\uc0c1 \uc218\ucef7<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc2dd\uc695 \uc5b5\uc81c \uad00\ucc30<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">MC4R \ud65c\uc131\ud654\uc5d0 \ubc18\uc751<\/td>\n<\/tr>\n<tr>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">OPA1 \uacb0\ud54d \uc218\ucef7<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc2dd\uc695 \uc5b5\uc81c \uad00\ucc30<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">OPA1 \uacb0\ud54d\uc5d0\ub3c4 \ubc18\uc751 \uc720\uc9c0<\/td>\n<\/tr>\n<tr style=\"background:#F3FBFD;\">\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">OPA1 \uacb0\ud54d \uc554\ucef7<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc2dd\uc695 \uc5b5\uc81c \ud6a8\uacfc \ud06c\uac8c \uac10\uc18c<\/td>\n<td style=\"border:1px solid #B8E9F2;color:#243447;padding:12px;\">\uc131\ubcc4\uc5d0 \ub530\ub978 \ubc18\uc751 \ucc28\uc774 \uac00\ub2a5\uc131 \uc81c\uc2dc<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc5f0\uad6c\uc9c4\uc740 \uc774\ub97c OPA1\uc774 \uc2e0\uacbd\uc138\ud3ec\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \uc720\uc9c0\ud558\uba74\uc11c \uc74c\uc2dd \uc12d\ucde8\uc640 \uccb4\uc911 \uc870\uc808\uc5d0 \uad00\uc5ec\ud55c\ub2e4\ub294 \uadfc\uac70 \uc911 \ud558\ub098\ub85c \ud574\uc11d\ud588\uc2b5\ub2c8\ub2e4. \ub2e4\ub9cc \uc138\ud2b8\uba5c\ub77c\ub178\ud0c0\uc774\ub4dc\ub294 \uc774 \uc5f0\uad6c\uc5d0\uc11c \uae30\uc804 \ud655\uc778\uc744 \uc704\ud574 \uc0ac\uc6a9\ub41c \uc57d\ubb3c\uc774\ub77c\ub294 \uc810\uc744 \uad6c\ubd84\ud560 \ud544\uc694\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ubc88 \uc0dd\uc950 \uc2e4\ud5d8 \uacb0\uacfc\ub97c \uadfc\uac70\ub85c \uac1c\uc778\uc774 \ube44\ub9cc \uce58\ub8cc\uc81c\ub97c \uc120\ud0dd\ud558\uac70\ub098 \uc0ac\uc6a9 \ubc29\ubc95\uc744 \ubcc0\uacbd\ud574\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4.<\/p>\n<h2 id=\"human-interpretation\" style=\"border-left:5px solid #0072CE;box-sizing:border-box;color:#00539F;font-size:1.55rem;line-height:1.45;margin:30px 0 16px;padding-left:12px;width:100%;max-width:100%;\">\uc0ac\ub78c\uc758 \uc2dd\uc695\uacfc \ube44\ub9cc\uc5d0 \ubc14\ub85c \uc801\uc6a9\ud574\ub3c4 \ub420\uae4c<\/h2>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uc544\uc9c1\uc740 \uc870\uc2ec\ud574\uc11c \ubd10\uc57c \ud569\ub2c8\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uc0dd\uc950\uc758 \ud2b9\uc815 \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c OPA1\uc744 \uc81c\uac70\ud55c \ub4a4 \ub098\ud0c0\ub098\ub294 \ubcc0\ud654\ub97c \uad00\ucc30\ud55c \uc2e4\ud5d8\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \u201c\uae30\ub984\uc9c4 \uc74c\uc2dd\uc744 \uc790\uc8fc \uba39\ub294 \uc0ac\ub78c\uc740 OPA1 \uae30\ub2a5\uc5d0 \ubb38\uc81c\uac00 \uc788\ub2e4\u201d\uac70\ub098 \u201cOPA1\uc744 \uc870\uc808\ud558\uba74 \uc0ac\ub78c\uc758 \ube44\ub9cc\uc744 \ud574\uacb0\ud560 \uc218 \uc788\ub2e4\u201d\uace0 \uacb0\ub860 \ub0b4\ub9b4 \ub2e8\uacc4\ub294 \uc544\ub2d9\ub2c8\ub2e4.<\/p>\n<ol style=\"background:#F3FBFD;border-left:4px solid #0072CE;border-radius:8px;box-sizing:border-box;color:#243447;line-height:1.85;margin:18px 0;padding:16px 18px 16px 42px;width:100%;max-width:100%;\">\n<li style=\"margin:7px 0;\"><strong style=\"color:#004B87;\">\uc0dd\uc950 \uc5f0\uad6c\ub77c\ub294 \uc810\uc744 \uba3c\uc800 \ud655\uc778\ud558\uae30<\/strong> \u2014 \uc0ac\ub78c\uc5d0\uac8c \uac19\uc740 \uacb0\uacfc\uac00 \ub098\ud0c0\ub09c\ub2e4\uace0 \ubc14\ub85c \ubcfc \uc218 \uc5c6\uc2b5\ub2c8\ub2e4.<\/li>\n<li style=\"margin:7px 0;\"><strong style=\"color:#004B87;\">\uc2dd\uc695\uc744 \uc758\uc9c0\ub9cc\uc758 \ubb38\uc81c\ub85c \ub2e8\uc815\ud558\uc9c0 \uc54a\uae30<\/strong> \u2014 \uc74c\uc2dd \uc12d\ucde8\uc5d0\ub294 \ub1cc \uc2e0\ud638\uc640 \ub300\uc0ac \ub4f1 \uc5ec\ub7ec \uc0dd\ubb3c\ud559\uc801 \uc694\uc778\uc774 \uad00\uc5ec\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<li style=\"margin:7px 0;\"><strong style=\"color:#004B87;\">\uc131\ubcc4 \ucc28\uc774\ub97c \uc0ac\ub78c\uc5d0\uac8c \uadf8\ub300\ub85c \ub300\uc785\ud558\uc9c0 \uc54a\uae30<\/strong> \u2014 \uc774\ubc88 \uc2e4\ud5d8\uc758 \ucc28\uc774\uac00 \uc778\uac04\uc5d0\uc11c\ub3c4 \ub3d9\uc77c\ud55c\uc9c0\ub294 \ucd94\uac00 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/li>\n<li style=\"margin:7px 0;\"><strong style=\"color:#004B87;\">\uc5f0\uad6c\uc6a9 \uc57d\ubb3c \ubc18\uc751\uc744 \uac1c\uc778 \uce58\ub8cc\ubc95\uc73c\ub85c \ud574\uc11d\ud558\uc9c0 \uc54a\uae30<\/strong> \u2014 \ube44\ub9cc \uce58\ub8cc\ub294 \uac1c\uc778\uc758 \uac74\uac15 \uc0c1\ud0dc\uc640 \uc758\ud559\uc801 \uc801\uc751\uc99d\uc744 \ubc14\ud0d5\uc73c\ub85c \ud310\ub2e8\ud574\uc57c \ud569\ub2c8\ub2e4.<\/li>\n<\/ol>\n<p style=\"color:#243447;line-height:1.9;margin:16px 0;\">\uadf8\ub798\ub3c4 \uc774\ubc88 \uc5f0\uad6c\uac00 \uc8fc\ub294 \uba54\uc2dc\uc9c0\ub294 \ud765\ubbf8\ub86d\uc2b5\ub2c8\ub2e4. \uc74c\uc2dd \uc12d\ucde8\uc640 \uccb4\uc911 \uc870\uc808\uc774 \ub2e8\uc21c\ud788 \uba39\uace0 \uc2f6\uc740 \ub9c8\uc74c \ud558\ub098\ub85c \uc124\uba85\ub418\ub294 \ud604\uc0c1\uc774 \uc544\ub2c8\ub77c, \uc2e0\uacbd\uc138\ud3ec \ub0b4\ubd80\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uae4c\uc9c0 \uc5bd\ud78c \ubcf5\uc7a1\ud55c \uacfc\uc815\uc77c \uc218 \uc788\ub2e4\ub294 \uc810\uc774\uc8e0. \uc55e\uc73c\ub85c \uc0ac\ub78c\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uac00 \uc774\uc5b4\uc838\uc57c \uc2e4\uc81c \ube44\ub9cc\uacfc \uce58\ub8cc \ubc18\uc751\uc5d0\uc11c OPA1\uc774 \uc5b4\ub5a4 \uc758\ubbf8\ub97c \uac16\ub294\uc9c0 \ub354 \ubd84\uba85\ud574\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><!-- INTERNAL LINK SLOT: \uc2dd\uc695 \uc870\uc808, \ube44\ub9cc \ub610\ub294 \uccb4\uc911 \uad00\ub9ac\uc640 \uad00\ub828\ub41c \uae30\uc874 \uc6cc\ub4dc\ud504\ub808\uc2a4 \uae00\uc758 \uc2e4\uc81c URL\uc744 \ud655\uc778\ud55c \ub4a4 \uc5f0\uacb0 --><br \/>\n<!-- STEP 3 END --><!-- STEP 4 START --><\/p>\n<section aria-label=\"\uc790\uc8fc \ubb3b\ub294 \uc9c8\ubb38\" style=\"box-sizing:border-box;margin:28px 0;width:100%;max-width:100%;\">\n<h2 style=\"color:#00539F;font-size:1.55rem;line-height:1.45;margin:0 0 16px;\">\uc790\uc8fc \ubb3b\ub294 \uc9c8\ubb38<\/h2>\n<details style=\"background:#FFFFFF;border:1px solid #B8E9F2;border-left:4px solid #0072CE;border-radius:10px;box-sizing:border-box;margin:10px 0;padding:14px 16px;width:100%;max-width:100%;\">\n<summary style=\"color:#004B87;cursor:pointer;font-weight:800;line-height:1.6;\">\uae30\ub984\uc9c4 \uc74c\uc2dd\uc744 \uc790\uc8fc \uba39\uace0 \uc2f6\ub2e4\uba74 OPA1\uc5d0 \ubb38\uc81c\uac00 \uc788\ub2e4\ub294 \ub73b\uc778\uac00\uc694?<\/summary>\n<p style=\"color:#243447;line-height:1.85;margin:12px 0 0;\">\uadf8\ub807\uac8c \ubcfc \uc218\ub294 \uc5c6\uc2b5\ub2c8\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \ud2b9\uc815 \uc2e0\uacbd\uc138\ud3ec\uc758 OPA1\uc744 \uc81c\uac70\ud55c \uc0dd\uc950\uc5d0\uc11c \uc9c0\ubc29 \uc12d\ucde8\uc640 \uccb4\uc911 \ubcc0\ud654\uac00 \ub098\ud0c0\ub0ac\ub2e4\ub294 \uacb0\uacfc\uc774\uba70, \uc0ac\ub78c\uc758 \uc74c\uc2dd \uc120\ud638 \uc6d0\uc778\uc744 OPA1 \ud558\ub098\ub85c \uc9c4\ub2e8\ud560 \uc218 \uc788\ub2e4\ub294 \uc758\ubbf8\ub294 \uc544\ub2d9\ub2c8\ub2e4.<\/p>\n<\/details>\n<details style=\"background:#FFFFFF;border:1px solid #B8E9F2;border-left:4px solid #0072CE;border-radius:10px;box-sizing:border-box;margin:10px 0;padding:14px 16px;width:100%;max-width:100%;\">\n<summary style=\"color:#004B87;cursor:pointer;font-weight:800;line-height:1.6;\">\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \uc554\ucef7 \uc0dd\uc950\uac00 \uc9c0\ubc29\uc5d0 \ub354 \ucde8\uc57d\ud588\ub2e4\ub294 \ub73b\uc778\uac00\uc694?<\/summary>\n<p style=\"color:#243447;line-height:1.85;margin:12px 0 0;\">OPA1\uc744 \uc81c\uac70\ud55c \uc870\uac74\uc5d0\uc11c\ub294 \uc9c0\ubc29 \uc12d\ucde8\uc640 \uccb4\uc911 \uc99d\uac00 \ubcc0\ud654\uac00 \uc554\ucef7\uc5d0\uc11c \ub354 \ud06c\uac8c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub2e4\ub9cc \uc774\ub97c \uc0ac\ub78c\uc758 \uc5ec\uc131\uc5d0\uac8c \uadf8\ub300\ub85c \uc801\uc6a9\ud560 \uc218\ub294 \uc5c6\uc73c\uba70, \uc5f0\uad6c\uc9c4\ub3c4 \uc131\ubcc4\uc5d0 \ub530\ub978 \uc0dd\ubb3c\ud559\uc801 \ucc28\uc774\ub97c \uc774\ud574\ud558\uae30 \uc704\ud55c \ub2e8\uc11c\ub85c \uc81c\uc2dc\ud55c \ub2e8\uacc4\uc785\ub2c8\ub2e4.<\/p>\n<\/details>\n<details style=\"background:#FFFFFF;border:1px solid #B8E9F2;border-left:4px solid #0072CE;border-radius:10px;box-sizing:border-box;margin:10px 0;padding:14px 16px;width:100%;max-width:100%;\">\n<summary style=\"color:#004B87;cursor:pointer;font-weight:800;line-height:1.6;\">\uc138\ud2b8\uba5c\ub77c\ub178\ud0c0\uc774\ub4dc\ub97c \uc0ac\uc6a9\ud558\uba74 \uae30\ub984\uc9c4 \uc74c\uc2dd\uc5d0 \ub300\ud55c \uc2dd\uc695\uc744 \uc904\uc77c \uc218 \uc788\ub098\uc694?<\/summary>\n<p style=\"color:#243447;line-height:1.85;margin:12px 0 0;\">\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc0dd\uc950\uc758 MC4R \uc2e0\ud638\uc640 OPA1\uc758 \uad00\uacc4\ub97c \ud655\uc778\ud558\uae30 \uc704\ud55c \uc2e4\ud5d8 \uacfc\uc815\uc5d0\uc11c \uc57d\ubb3c \ubc18\uc751\uc744 \uc0b4\ud3b4\ubcf8 \uac83\uc785\ub2c8\ub2e4. \uc774 \uacb0\uacfc\ub9cc\uc73c\ub85c \uc77c\ubc18\uc801\uc778 \uc2dd\uc695 \uc870\uc808 \ubaa9\uc801\uc73c\ub85c \uc57d\ubb3c\uc744 \uc0ac\uc6a9\ud560 \uc218 \uc788\ub2e4\ub294 \uc758\ubbf8\ub294 \uc544\ub2c8\uba70, \ube44\ub9cc \uce58\ub8cc\uc81c \uc0ac\uc6a9 \uc5ec\ubd80\ub294 \uc758\ud559\uc801 \uc801\uc751\uc99d\uacfc \uac1c\uc778 \uc0c1\ud0dc\uc5d0 \ub530\ub77c \uc758\ub8cc \uc804\ubb38\uac00\uac00 \ud310\ub2e8\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n<\/details>\n<\/section>\n<p><!-- STEP 4 END --><!-- STEP 5 START --><\/p>\n<div style=\"background:#F3FBFD;border:1px solid #B8E9F2;border-top:4px solid #0072CE;border-radius:12px;box-sizing:border-box;margin:26px 0;padding:18px 20px;width:100%;max-width:100%;\">\n<p style=\"color:#004B87;font-size:1.12rem;font-weight:800;line-height:1.6;margin:0 0 10px;\">\uae30\ub984\uc9c4 \uc74c\uc2dd\uc5d0 \ub04c\ub9ac\ub294 \ud604\uc0c1\ub3c4 \uc0dd\uac01\ubcf4\ub2e4 \ubcf5\uc7a1\ud55c \ub1cc\uc758 \uc870\uc808 \uacfc\uc815\uacfc \uc5f0\uacb0\ub3fc \uc788\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p style=\"color:#243447;line-height:1.9;margin:0;\">\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c\ub294 MC4R \uc2e0\uacbd\uc138\ud3ec\uc758 OPA1\uc744 \uc81c\uac70\ud55c \uc0dd\uc950\uc5d0\uc11c \uba39\uc774\uc640 \uc9c0\ubc29 \uc12d\ucde8\uac00 \ub298\uace0 \uccb4\uc911 \uc99d\uac00\uac00 \ucee4\uc9c0\ub294 \ubcc0\ud654\uac00 \ud655\uc778\ub410\uc73c\uba70, \uadf8 \uc591\uc0c1\uc740 \uc131\ubcc4\uc5d0 \ub530\ub77c\uc11c\ub3c4 \ub2ec\ub790\uc2b5\ub2c8\ub2e4. \ub2e4\ub9cc \uc544\uc9c1 \uc0dd\uc950 \uc2e4\ud5d8 \ub2e8\uacc4\uc774\uae30 \ub54c\ubb38\uc5d0 \uc0ac\ub78c\uc758 \uc2dd\uc695\uc774\ub098 \ube44\ub9cc \uc6d0\uc778\uc744 OPA1 \ud558\ub098\ub85c \uc124\uba85\ud558\uac70\ub098 \ud2b9\uc815 \uce58\ub8cc\ubc95\uc73c\ub85c \uc5f0\uacb0\ud574\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4. \uc624\ud788\ub824 \uc2dd\uc695\uacfc \uccb4\uc911 \uc870\uc808\uc774 \ub2e8\uc21c\ud55c \uc758\uc9c0\uc758 \ubb38\uc81c\uac00 \uc544\ub2c8\ub77c \uc2e0\uacbd\uc138\ud3ec\uc758 \ub300\uc0ac\uc640 \uc5ec\ub7ec \uc0dd\ubb3c\ud559\uc801 \uc2e0\ud638\uac00 \ud568\uaed8 \uc791\uc6a9\ud558\ub294 \ubcf5\uc7a1\ud55c \uacfc\uc815\uc77c \uc218 \uc788\ub2e4\ub294 \uc810\uc5d0 \uc758\ubbf8\uac00 \uc788\uc5b4 \ubcf4\uc5ec\uc694. \uc5ec\ub7ec\ubd84\ub3c4 \uc720\ub3c5 \uae30\ub984\uc9c4 \uc74c\uc2dd\uc774 \ub2f9\uae30\ub294 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\ub1cc\uc758 \uc5ec\ub7ec \uc2e0\ud638\uac00 \ubcf5\uc7a1\ud558\uac8c \uad00\uc5ec\ud569\ub2c8\ub2e4. \uc77c\ubcf8 \uc624\uc0ac\uce74\uacf5\ub9bd\ub300 \uc5f0\uad6c\uc9c4\uc740 \uadf8\uc911\uc5d0\uc11c\ub3c4 \uc2dc\uc0c1\ud558\ubd80\uc758 \uba5c\ub77c\ub178\ucf54\ub974\ud2f4-4 \uc218\uc6a9\uccb4(MC4R) \uc2e0\uacbd\uc138\ud3ec\uc5d0 \uc788\ub294 OPA1(optic atrophy 1)\uc774\ub77c\ub294 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